Method for quantitative analysis of interactions between...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007100, C436S501000, C436S518000, C422S050000

Reexamination Certificate

active

07816094

ABSTRACT:
A method for quantitative analysis of interactions between fluorescein-labeled HIF-1α (alpha) C-terminal peptides and cAMP-responsive element binding protein (CBP) or p300 proteins, and a method of screening inhibitors against the formation of HIF-1α-p300 or HIF-1α-CBP protein complexes using the above method is described.

REFERENCES:
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patent: 2005-526515 (2005-09-01), None
Freedman et al. (Proceedings of the National Academy of Sciences of the Untied States of America, Apr. 16, 2002, vol. 99, No. 8., pp. 5367-5372).
Vleugel et al. (Human Pathology, Aug. 2006, vol. 37., No. 8, pp. 1085-1092).
Burke et al. (Combinatorial Chemistry & high Throughput Screening, 2003 vol. 6, pp. 183-194).
NCBI, AAC51770, CREB-binding protein, NCBI Sequence View web site, http://www.ncbi.nlm.nih.gov/, Sep. 29, 1997, pp. 1-3.
NCBI, XP 001168473, Predicted: E1A binding protein p300 isoform 2 [Pan troglodytes], NCBI Sequence View web site, http://www.ncbi.nlm.nih.gov/, Sep. 16, 1996, pp. 1-3.

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