Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-02-15
2005-02-15
Andres, Janet (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007950, C530S399000
Reexamination Certificate
active
06855505
ABSTRACT:
The present invention relates to a method for quantifying the amount of active transforming growth factor beta (TGF-β) in biological samples. In particular the method comprising incubating cryosections of a tissue with cells which contain a TGF-β responsive expression vector having a structural region encoding an indicator protein and measuring the amount of said indicator protein expressed from the cells.
REFERENCES:
patent: 9519987 (1995-07-01), None
Abe M et al.: “An Assay for Transforming Growth Factor-Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct” Analytical Biochemistry, vol. 216, No. 2, 2/1994, pp. 276-284.
Shah M et al.: “Control of Scarring in Adult Wounds by Neutralising Antibody to Transforming Growth Factor Beta” Lancet The, vol. 339, Jan. 1992, pp. 213/214.
Yang, Liju et al.: “Active transforming growth factor-beta. in wound repair: determination using a new assay” Am. J. Pathol., 154(1), 105-111 Jan. 1999.
Blewett et al, “Regenerative Healing of Incisional Wounds in Murine Fetal Lungs Maintained in Organ Culture”, J. Pediatric Surgery 30(7):945-948 (1995).
Barcellos-Hoff et al, “Immunohistochemical Detection of Active Transforming Growth Factor-β in Situ Using Engineered Tissue”, American J. Pathology 147:1228-1237 (1995).
Brunner Georg
Ferguson Mark W. J.
Andres Janet
Nixon & Vanderhye P.C.
Renovo Limited
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