Method for quantifying sphingosine and for diagnosing platelet a

Details Method for quantifying sphingosine and for diagnosing platelet a Method for quantifying sphingosine and for diagnosing platelet a

1995-06-29

1997-10-14

Snay, Jeffrey

Chemistry: analytical and immunological testing

Including use of radioactive properties

436 63, 436 71, 436111, G01N 3350

Patent

active

056771894

ABSTRACT:
A method of detecting sphingosines and platelet activation is disclosed.

REFERENCES:
Yatomi, Y. et al. Analytical Biochemistry, vol. 230, pp. 315-320 (1995) 1995.
Yatomi, Y. et al. Blood, vol. 86, No. 1, pp. 193-202 (Jul. 01, 1995) Jul. 1995.
Stryer, L. "Biochemistry" W.H. Freeman and Company, New York, pp. 461-462 (1981) 1981.
Yatomi, Y. et al. "Quantitative Measurement of Sphingosine 1-Phosphate in Biological Samples by Acylation with Radioactive Acetic Anhydride" Analytical Biochemistry, vol. 230, pp. 315-320 (1995) 1995.
Amemiya, Y. et al. "Imaging Plate Illumnates Many Fields" Nature, vol. 336, pp. 89-90 (1988) Nov. 03, 1988.
Merrill, A.H. Jr. et al. "Quantitation of Free Sphingosine in Liver by High-Performance Liquid Chromatography" Analytical Biochemistry, vol. 171, pp. 373-381 (1988) 1988.
Vunnam, R.R. et al. "Short Chain Ceramides as Substrates for Glucocerebroside Synthetase" Biochimica et Biophysica Acta, vol. 573, pp. 73-82 (1979) 1979.
Yutaka Yatomi et al., "N,N-Dimethylsphingosine Inhibition of Sphingosine Kinase and Sphingosine 1-Phosphate Activity in Human Platelets", Biochem., 35:626-633, (1996).
Hideki Ohta et al., "Quantification of Free Sphingosine in Culture Cells by Acylation with Radioactive Acetic Anhydride", Analyt. Biochem., 222:489-494, (1994).
Yasayuki Igarashi et al., "The Relationships of Sphingosine-1-Phosphate Content in the Plasma from Platelet Samples with Transfusion Reactions", (Abstract of paper presented at the Second Meeting of European Haematology Association, Paris, France, 29 May--1 Jun. 1996).

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