Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-08-09
2011-08-09
Cook, Lisa (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S002000, C435S007100, C436S501000, C436S518000, C436S522000, C422S050000
Reexamination Certificate
active
07993859
ABSTRACT:
The present invention relates to methods for detecting a oxidative stress in a biological sample, methods of determining a cumulative record of oxidative injury, and methods of diagnosing diseases of aging, such as cardiovascular diseases, based on the presence or absence of a biomarker or a component thereof. The present invention also relates to a kit for detecting oxidative stress in a biological sample comprising a stabilizing reactant and an antibody. In some embodiments of the invention, the biomarker of oxidative stress is selected from an aldehyde-protein adduct and an aldehyde metabolite-protein adduct, and the proposed method further comprises measuring separately for the same protein biomarkers of oxydative stress formed with different amino acids of the protein.
REFERENCES:
Veronneau, M. et al Quantitative Gas Chromatographic—I Mass Spectrometr C Rad C. Biol. Med 33:1380-1388; Aug. 2002.
Crabb, John W. et al Hydroxynonenal Inactives Cathepsin B. Protein Science 2002 11:831-840 Dec. 2001 USA.
Des Rosiers Christine
Lesgards Jean-Francois
Tardif Jean-Claude
Cook Lisa
Dowell & Dowell , P.C.
Institut de Cardiologie de Montreal
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