Method for quantifying alcohol catabolism

Details Method for quantifying alcohol catabolism Method for quantifying alcohol catabolism

1996-10-25

1998-07-21

Alexander, Lyle A.

Chemistry: analytical and immunological testing

Oxygen containing

Hydroxyl containing

436900, G01N 33497

Patent

active

057834490

ABSTRACT:
The method for quantifying Alcohol Breakdown Activity (ABA) in humans in vivo is developed to determine an efficiency of alcohol catabolism for any given individual. Unlike other related methods, Index-K uses a biological regularity of ABA and employs a third dimension for integrating the multiple pharmacokinetical data into a single value. As expected, it allows for the discrimination between human differences, including gender and personal levels of alcohol dependency. Its use of pharmacokinetical data from ethanol catabolism makes it absolutely specific to alcohol--a major cause of alcohol disorder. This feature allows us to help diagnose alcoholism even in cases where traditional methods used to evaluate harmful alcohol consumption have failed.

REFERENCES:
Biosis 96:196365, 1996.
Fujimiya et al., "Problems in pharmacokinetic analysis of alcohol disposition: A trial of the Bayesian least-squares method", Alcoholism Clinical and Experimental Research 20(1 suppl.). 1996, 2A-6A, ISSN:0145-6008. Biosis 96:196365 abstract.

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