Method for purifying water-insoluble polyene antibiotics

Details Method for purifying water-insoluble polyene antibiotics Method for purifying water-insoluble polyene antibiotics

1980-10-06

1981-12-29

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1708

Patent

active

043083757

ABSTRACT:
A method for purifying water-insoluble polyene antibiotics, such as amphotericin and nystatin, is provided which method includes the step of passing a mixture of the polyene antibiotic dispersed in methanol through an ion exchange column whereby gram positive and gram negative bacteria are removed from the antibiotic.

REFERENCES:
patent: 3945993 (1976-03-01), Schaffner et al.
patent: 4177265 (1979-12-01), Michel et al.
Slejko, Chem. Absts., 90:76094n, p. 251 (1979), "Removal of Biological Matter from Aqueous Streams Via Ion Exchange Filtration".
Schubert, Chem. Absts., 85:83086m, p. 333 (1976), "On Bacterial Aftergrowth in Drinking and Industrial Water II. Apparative and Processing Effects on the Growth of Bacteria and the Possibility of Disinfection on Ion Exchange Resin Systems".
Kuehne, Chem. Absts., 74:130263b, p. 318 (1971), "Ion Exchange or Activated Charcoal Filter Contaminated with Microbial Impurities".
Rohm and Haas Co., Chem. Absts., 91:198601s, p. 354 (1979), "Bacteria Removal from Liquid Media by Ion Exchange Column".
Semmens, Chem. Absts., 90:11888e, p. 342 (1979), "Water Purification Process".
Ogoshi, Chem. Absts., 90:192358a, p. 350 (1979), "Ultrapure Water".

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