Method for purifying protected 2′-deoxycytidines and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S023100, C536S025340, C536S025310, C536S025300, C536S025400, C536S026800, C536S028510, C536S022100, C546S044000, C530S330000, C514S203000, C514S049000

Reexamination Certificate

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06936709

ABSTRACT:
A protected 2′-deoxycytidine is purified by precipitating the protected 2′-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the protected 2′-deoxycytidine and water, and by recovering the protected 2′-deoxycytidine:wherein R1 represents a 4-methoxytrityl, 4, 4′-dimethoxytrityl, or triphenylmethyl group; and B1 represents a cytosine group having a protected amino group. The compound represented by general formula (3) is, in particular, a protected 2′-deoxycytidine represented by formula (4):The 2′-deoxycytidine is used as a raw material for antisense DNA.

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patent: 00/75154 (2000-12-01), None

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