Method for purifying interferon

Details Method for purifying interferon Method for purifying interferon

1982-06-07

1984-08-14

Hazel, Blondel

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, C07C10352, A61K 4502

Patent

active

044656220

ABSTRACT:
A method for purifying interferon having anti-cancer effects or anti-viral effects, wherein highly purified interferon can be easily obtained by a single operation in a recovery of about 100%. In this method, interferon is obtained by specifically adsorbing interferon onto a carrier containing acrylonitrile polymer and eluting the adsorbed interferon with an appropriate buffer.

REFERENCES:
patent: 4168261 (1979-09-01), Edy
patent: 4172071 (1979-10-01), De Maeyer et al.
Chemical Abstracts, vol. 90, p. 274, Abst. No. 156689a, 1979.
Rubinstein et al., Arch. Biochem. Biophys., vol. 210, pp. 307-318, 1981.
Whitman et al., J. Interferon Research, vol. 1, pp. 305-312, 1981.
Heine et al., J. Gen. Virol., vol. 54, pp. 47-56, 1981.
Yip et al., Proc. Natl. Acad. Sci., vol. 78, pp. 1601-1605, 1981.
Yonehara et al., J. Biol. Chem., vol. 256, pp. 3770-3775, 1981.
Knight, Jr. et al., J. Biol, Chem., vol. 256, pp. 3609-3611, 1981.

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