Method for purifying FSH

Details Method for purifying FSH Method for purifying FSH

1998-05-08

1999-11-23

Moezie, F. T.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Glycoprotein, e.g., mucins, proteoglycans, etc.

530397, 530350, 530412, 530413, 530415, 530344, C07K 318, C07K 320, C07K 328

Patent

active

059902884

ABSTRACT:
The present invention provides a method for purifying follicle stimulating hormone (FSH) from biological samples, for example, from human pituitary glands or human postmenopausal urine, wherein the FSH is contaminated with other proteins, by use of dye-ligand affinity chromatography (DAC). This process may be used to generate affinity pure FSH suitable for therapeutic applications.

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patent: 5128453 (1992-07-01), Arpaia et al.
patent: 5173404 (1992-12-01), diZerega
patent: 5661126 (1997-08-01), Donahoe
Declaration of James R. Musick and Erik Van Horn.
International Search Report.
Jack, G.W., "Immunoaffinity Chromatography," Mol. Biotechnology, 1,, pp. 59-86 (1994).
Lowe, C.R. et al,, "Designer dyes: `biomimetic` ligands for the purification of pharmaceutical proteins by affinity chromatography," Tibtech, 10, pp. 442-448 (1992).
Moore, L.G., et al, "Follicle-Stimulating Hormone in the Brushtail Possum (Trichosurus vulpecula): Purification, Characterization, and Radioimmunoassay," Gen. Comp. Endo., 106, pp. 30-38 (1997).

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