Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-11-30
1992-06-09
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 54, 514 57, 514802, 530399, 530350, 530413, 530383, C12N 1500, C07K 320, C07K 1300, C12P 2102
Patent
active
051207150
ABSTRACT:
Disclosed is a method for purifying a fibroblast growth factor (FGF) protein with use of a crosslinked polysaccharide sulfate. The FGF protein is preferable a mutein, in which at least one human basic FGF-constituent amino acid is substituted by at least one different amino acid. The crosslinked polysaccharide sulfate is preferably a crosslinked cellulose sulfate, a crosslinked agarose sulfate or a crosslinked dextran sulfate. According to the present invention, FGF can be highly purified on a commercial scale, and therefore preparations containing the FGF protein can be advantageously formulated.
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Kajio Tomoko
Kato Koichi
Kawahara Kenji
Conlin David G.
Griffin Ronald W.
Linek Ernest V.
Resnick David S.
Takeda Chemical Industries Ltd.
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