Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1985-02-01
1988-05-10
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530384, 530412, 530413, 530415, 210656, 210927, 514822, 424101, C07G 700, A61K 3514, A61K 3516, C07K 320
Patent
active
047436808
ABSTRACT:
Disclosed are methods for purifying proteins including AHF by column chromatography in the presence of additives including sugars and polyhydric alcohols which serve to increase the electrostatic forces on the surface of said proteins while decreasing the hydrophobicity of said proteins resulting in preparations of such proteins of high purity and/or resolution and/or recovery.
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patent: 4404132 (1983-09-01), Mitra
patent: 4439357 (1984-03-01), Bonhard et al.
patent: 4508709 (1985-04-01), Amphlett et al.
Lundblad et al, "The Effect of Dextrose on Chromatography of Antihemophilic Factor (Factor VIII), Thrombosis Research, 1:197, 1972, pp. 197-200.
Austen et al, "Factor VIII Fractionation on Aminohexyl Sepherose with Possible Reduction in Hepatitis B Antigen", Thromb. Haemastas., 48(1): 46 (1982).
Faure et al, "Improved Buffer for the Chromatographic Separation of Factor VIII Coagulant", J. Chromatog., 257:387 (1983).
Johnson Alan J.
Mathews Rita W.
Kight John
New York University
Nutter Nathan M.
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