Method for purifying and isolating carboxyl-terminal peptides

Details Method for purifying and isolating carboxyl-terminal peptides Method for purifying and isolating carboxyl-terminal peptides

1989-03-09

1992-04-14

Robinson, Douglas W.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530344, 530345, 436 89, 436 90, C07K 1706, C07K 114, G01N 3300

Patent

active

051049732

ABSTRACT:
This invention provides a method for purifying and isolating a carboxyl-terminal peptide. A peptide bond between a lysine residue in a polypeptide and the adjacent amino acid residue is specifically cleaved on its carboxyl-terminal side. The resulting peptide mixture is then reacted with a solid carrier possessing on its surface functional groups capable of reacting and covalently bonding with free amino groups. Subsequently the peptide bond between the aminoterminal amino acid residue and the adjacent amino acid residue of each peptide is cleaned by acid treatment, and the peptides thus released from the solid carrier are isolated.

REFERENCES:
European Search Report.

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