Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1991-12-12
1994-04-05
Wityshyn, Michael G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
530412, 530418, 530419, 530427, 530350, 530825, 435 681, 435891, C07K 324, A23J 320
Patent
active
053006321
ABSTRACT:
The present invention provides a method for purification of a surface exposed, immunogenic outer membrane protein of Haemophilus influenzas which is conserved amongst strains. The protein, designated P6, is relatively free of detergent, contaminating RNA and undesirable cellular components.
In accordance with the present invention, there is provided a method for purifying an immunogenic outer membrane protein of H. influenzas consisting essentially of:
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patent: 4459286 (1984-07-01), Hilleman et al.
patent: 4474758 (1984-10-01), Kuo et al.
Munson, Jr. et al., "Purification and Partial Characterization of Outer Membrane Proteins P5 and P6 from Haemophilus influenzae Type b", Infection and Immunity, vol. 49, No. 3, 544-549, Sep., 1985.
Murphy et al., "Identification of a 16,600-Dalton Outer Membrane Protein on Nontypeable Haemophilus influenzae as a Target for Human Bactericidal Antibody", The Amer. Soc. for Clin. Inv., vol. 78 1020-1027, Oct. 1986.
Apicella Michael A.
Murphy Timothy F.
Research Foundation of State University of New York
Sayala C.
Wityshyn Michael G.
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