Liquid purification or separation – Processes – Ion exchange or selective sorption
Reexamination Certificate
2003-08-05
2008-09-02
Naff, David M (Department: 1657)
Liquid purification or separation
Processes
Ion exchange or selective sorption
C424S094300, C435S177000, C435S180000, C435S181000, C435S188000, C514S002600, C525S054100, C530S402000, C530S815000, C530S816000
Reexamination Certificate
active
07419600
ABSTRACT:
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structurewherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polyaand polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structurewhere mPEGaand mPEGbhave the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.
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Caliceti Paola
Harris J. Milton
Schiavon Oddone
Veronese Francesco Maria
Evans Susan T.
Naff David M
Nektar Therapeutics AL, Corporation
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