Method for purification of ibuprofen comprising mixtures

Details Method for purification of ibuprofen comprising mixtures Method for purification of ibuprofen comprising mixtures

1990-09-06

1992-09-29

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5142

Patent

active

051515512

ABSTRACT:
This invention pertains to a method of purifying ibuprofen-comprising reaction product mixtures. The method of purification is based on crystallization of ibuprofen from a hydrocarbon solvent and the discovery that there are impurity complexes in the ibuprofen-comprising reaction product mixtures which cannot be removed by crystallization from a hydrocarbon solvent.
The method of the invention includes at least one step in which the impurity complex in a first ibuprofen-comprising mixture is destabilized or broken up, followed by crystallization of the ibuprofen from a second solution or mixture comprising the first ibuprofen-comprising mixture, whereby the impurities which were previously complexed can then be removed from the ibuprofen by the crystallization of ibuprofen from a solvent.

REFERENCES:
patent: 4476248 (1984-10-01), Gordon
patent: 4709089 (1987-11-01), Shimizu
patent: 4981995 (1991-01-01), Elango et al.

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