Method for purification of hepatitis B virus surface antigen

Details Method for purification of hepatitis B virus surface antigen Method for purification of hepatitis B virus surface antigen

1984-03-06

1985-05-07

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112B, 424 89, 424 86, A61K 3912, A61K 3900, A61K 3942, C07G 700

Patent

active

045157146

ABSTRACT:
An improved method for the purification of hepatitis B virus surface anti by column chromatography, which is characteristic in using as a gel for the chromatography a sulfuric acid ester of a crosslinked polysaccharide or cellulose which is obtained by sulfating a crosslinked polysaccharide or cellulose. Said method can give a highly purified hepatitis B virus surface antigen which is useful for the preparation of hepatitis B virus vaccine.

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Proc. Nat. Acad. Sci., U.S.A., 72, No. 3, 1975, 1055-1058, Wilchek et al.

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