Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1984-10-01
1986-09-16
Hazel, Blondel
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
424 88, 424 89, 530403, 530404, 530406, C12P 2100, A61K 3929
Patent
active
046122834
ABSTRACT:
A method for purification of HBs antigen, which comprises treating an HBs tigen-containing material with an acid, optionally subjecting to salting out with ammonium sulfate, and subjecting the material to a chromatography with hydroxyapatite, by which a highly purified HBs antigen suitable for the preparation of HBV vaccine or diagnostic agent can be obtained in an industrial scale. This method is particularly useful for the purification of HBs antigen-containing material produced by recombinants obtained by DNA recombination technique.
REFERENCES:
patent: 4301250 (1981-11-01), McAleer et al.
patent: 4442205 (1984-04-01), Hamer et al.
patent: 4515714 (1985-05-01), Kauahara et al.
Hitzeman, R. et al., Nucleic Acid Research, vol. 11, pp. 2745-2763, 1983.
Hamada Fukusaburo
Miake Fumio
Nozaki Chikateru
Ohtomo Nobuya
Sugahara Keishin
501 Juridical Foundation, The Chemo-Sero-Therapeutic Research In
Hazel Blondel
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