Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1998-09-24
2000-07-25
Low, Christopher S. F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
530380, 530392, 530393, 530395, 530412, 530427, 530830, C07K 1400, A61K 3514, A23J 100
Patent
active
060938048
ABSTRACT:
The methods of the present invention provide a simple means for separating active and inactive Alpha Proteinase Inhibitor (API). The methods further provide means for purifying API at high yield (>70%), and at levels of purity (>90%) and activity (>90%) not heretofore available. Moreover, the methods of the present invention are simple (i.e., two chromatographic steps) and efficient; and are thus especially suitable to large scale purification processes. These methods will contribute substantially to alleviating the unmet demand for API for therapeutic purposes.
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Drohan William H.
Ralston Annemarie H.
American National Red Cross
Low Christopher S. F.
Mohamed Abdel A.
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