Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1992-11-24
1994-04-19
Yasko, John D.
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
128898, 606195, A61M 3100
Patent
active
053041224
ABSTRACT:
A model of arterial restenosis in domestic pigs using deep injury to the coronary arterial media resulting in extensive proliferative response. Metal wire coils are delivered percutaneously to the coronary arteries of pigs with an oversized, high pressure (14 atm) balloon and left in place for 5-6 weeks. During placement, the balloon expands the coils and delivers them securely within the arterial lumen causing fracture of the internal elastic lamina by the coil. An extensive proliferative response occurs and is associated with a lumenal area narrowing of at least 50% Immunohistochemical studies confirms the prominence of smooth muscle cells in the tissue. The histopathologic features of the proliferative response are identical to those observed in cases of restenosis post-angioplasty.
This model closely mimics the proliferative portion of human restenosis both grossly and microscopically. It may thus be useful for understanding human restenosis and for testing therapies aimed at preventing restenosis after balloon angioplasty or other coronary interventional procedures.
REFERENCES:
patent: 4886062 (1992-12-01), Witkor
Schwartz, A Practical Porcine Model of Human Coronary Artery Restenosis Post PTCA, Abstract, JACC vol. 15, No. 2, Feb. 1990: 165A.
"A Cascade Model for Restenosis. A Special Case of Atherosclerosis Progression", by P. Libby et al., Circulation 86(6) III-47-52, Dec., 1992.
"Restenosis After Balloon Angioplasty-A Practical Proliferative Model in Porcine Coronary Arteries", by Robert S. Schwartz et al., Circulation, 82(6):2190-2200, Dec., 1990.
"Restenosis and the Proportional Neointimal Response to Coronary Artery Injury: Results in a Porcine Model" by Robert S. Schwartz, et al., J. Am. Coll. Cardiol; 19; 267-274, Feb., 1992.
"The Restenosis Paradigm Revisted: An Alternative Proposal for Cellular Mechanisms" [editorial], Robert S. Schwartz et al., J. Am. Coll. Cardiol; 20(5) 1284-1293, Nov., 1992.
Hull Vincent W.
Murphy Joseph G.
Schwartz Robert S.
Wolff Rodney G.
Gutowski Anthony
Latham Daniel W.
Medtronic Inc.
Patton Harold R.
Yasko John D.
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