Method for providing a neuroprotective effect to the mammalian e

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514569, 514737, 514516, 514912, 514913, 424 7804, A01K 31195

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active

058666052

ABSTRACT:
Pharmaceutical compositions and a method are disclosed for providing neuroprotective effect to the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon 20 atoms, that may be derived from a lower alkanol.

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Ueda et al, "Chloride currents in freshly isolated rat retinal pigment epithelial cells", Exp Eye Res, Mar. 1994, 58 (3) pp. 331-342.
Zeevalk et al, "Excitatory amino acid-induced toxicity in chick retina: amino acid release, histology, and effects of chloide channel blockers", J. Neurochem, 1989, pp. 1610-1619.
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Zhang et al, "Tamoxifen blocks chloride channels. A possible mechanism for cataract formation", J. Clin Invest, 1994, 94/4, pp. 1690-1697.
Zhang et al, "ATP-activated chloride channel inhibited by an antibody to P glycoprotein", Am J Physiol, 1994, P C1095-1102.

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