Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-09-17
1995-03-21
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424417, 424418, A61K 3722
Patent
active
053993314
ABSTRACT:
This invention relates to a method for synthesizing a substantially pure reactive lipid including, for example, N-[4-(p-maleimidophenyl)-butyryl]phosphatidylethanolamine (MPB-PE) and related compositions. The compositions of the present invention are useful as coupling agents and may be incorporated into liposomes and subsequently coupled to proteins, cofactors and a number of other molecules. A preferred coupling method is also disclosed as are protein conjugates.
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Bally Marcel B.
Choi Lewis S.
Cullis Pieter R.
Loughrey Helen C.
Phelan D. Gabrielle
Rubin Kenneth B.
The Liposome Company Inc.
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