Method for protection of swine against pleuropneumonia

Details Method for protection of swine against pleuropneumonia Method for protection of swine against pleuropneumonia

1990-11-20

1994-07-26

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424520, 514 54, A61K 39102, A61K 3574, A61K 31715

Patent

active

053325729

ABSTRACT:
The respiratory mucosa of swine are sensitized for the production of protective IgA antibodies on infection with Actinobacillus (Haemophilus) pleuropneumoniae by prior administration of a vaccine comprising a protease lysate of the outer membrane (OM) of A. pleuropneumoniae cells. The lysate contains native OM lipopolysaccharide together with a protease digest of OM protein. Preferably two doses of the vaccine are successively administered to provide protective antibodies in the respiratory mucosa prior to infection.

REFERENCES:
patent: 4789544 (1988-12-01), Nelson et al.
Rapp et al., Infect. Immun., vol. 54 No. 3, Dec. 1986, pp. 751-760.
Fenwick et al., Infect. Immun., vol. 54 No. 2, Nov. 1986, pp. 575-582.
Inzana et al., Infect. Immun., vol. 56 (1988), pp. 1880-1889.
Cash et al., J. of Inf. Dis., vol. 130, No. 4, p. 325 (Oct. 1974).
Eisenstein et al. J. of Inf. Dis., vol. 150, No. 3, p. 425 (Sep. 1984).
Olander et al., Microbial Pathogenesis 1990, 8:37-45.

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