Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1995-06-07
1999-02-09
Degen, Nancy
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
514 43, 514 76, 514269, 514299, 514546, 514663, 514917, C12N 506, A61K 3170, A61K 3113, A61K 31685
Patent
active
058693386
ABSTRACT:
A method and pharmaceutical for protecting against mutational damage in mammalian cells, irrespective of the nature of the mutagenic event or source of radiational or chemical insult or the like.
REFERENCES:
patent: 5292497 (1994-03-01), Schein et al.
patent: 5298499 (1994-03-01), Carroll et al.
patent: 5434145 (1995-07-01), Edwards et al.
patent: 5488042 (1996-01-01), Grdina
patent: 5567686 (1996-10-01), Grdina
"Abstracts," 3.sup.rd International Conference on Anticarcinogenesis & Radiation Protection, Oct. 15-21, 1989.
"Abstracts," Twenty-eighth Plenary Meeting of the Committee on Space Research, Jun. 26-Jul. 6, 1990.
Applegate, L.A., Lautler, D. and Tyrrell, R.M., "Endogenous Glutathoine Levels Modulate the Frequency of Both Spontaneous and Long Wavelength Ultraviolet Induced Mutations in Human Cells," Carcinogenesis, 13(9):1557-1560, 1992.
Benova, D., "Antimutagenic Properties of WR 2721 and of a Radioprotective Mixture, ATP-AET-Serotonin, With Regard to X Ray Induced Reciprocal Translocations in Mouse Spermatogonia," Int. J. Radiation Oncology Biol. Phys., 13, 117-119, 1987.
Brown, J.M., Sensitizers and Protectors and Radiotherapy, Cancer, 2222-22228, May 1 Supplement, 1985.
Carnes, B.A. and Grdina, D.J., "In Vivo protection by the Aminothiol WR-2721 Against Neutron-Induced Carcinogenesis," Int. J. Radiat. Biol., 61, 567-576, 1992. (Supported in part by the U.S. Department of Energy, Office of Health and Environment Research, under contract W-31-109-ENG-38, the Center of Radiation Therapy and NIH-NCI grant CA-37435.).
Constine, L.S., Zagars, G., Rubin, P., and Kligerman, M., "Protection by WR-2721 of Human Bone Marrow Function Following Irradiation," Int. J. Radiation Oncology Biol. Phys., 12:1505-1508, 1986.
Corn, B.W., Liber, H.L., and Little, J.B., "Differential Effects of Radical Scavengers on X-Ray-Induced Mutation and Cytotoxicity in Human Cells," Radiation Research, 109:100-108, 1987.
Fry, R.J.M., "Radiation Carcinogenesis: Radioprotectors and Photosensitizers," Radioprotectors and Anticarcinogens, 417-436, 1983. (Supported by the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with the Union Carbide Corporation).
Grdina, D.J., P. Dale, and R. Weichselbaum. Protection Against AZT-Induced Mutagenesis at the HGPRT Locus in a Human Cell Line by WR-151326. International Journal of Radiation Oncology, Biology, Physics, 22:813-815, 1992. Presented at the Seventh International Conference on Chemical Modifiers for Cancer Treatment, Clearwater, Florida, Feb. 2-5, 1991. (Supported in part by the U.S. Department of Energy, Office of Health and Environmental Research, under contract W-31-109-ENG-38;NIH/NCI grant CA-37435, U.S. Bioscience Inc. and the Center for Radiation Therapy.).
Grdina, D.J., B.A. Carnes, D. Grahn, and C.P. Sigdestad. Protection Against Late Effects of Radation by S-2-(3-Aminopropylamino)-Ethylphosphorothioic Acid. Cancer Research, 51:4125-4130, 1991. (Supported by the U.S. Department of Energy, under contract W-31-109-ENG-38; by NIH/NCI grant CA-37435 and by the center for Radiation Therapy.).
Grdina, D.J., B. Nagy, C.K. Hill, and C.P. Sigdestad. Protection Against Ethanethiol Under Conditions of Acute Hypoxia. Radiation Research, 117:251-258, 1989.
Grdina, D.J. and C.P. Sigdestad. Radiation Protectors: The Unexpected Benefits. Drug Metabolism Reviews, 20(1):13 42, 198. (Supported in part by the U.S. Department of Energy, Office of Health and Environmental Research under contract W-31-103-ENG-38 and Public Health Service grant CA37435 awareded (D.J.G.) by the National Cancer Institute, Department of Human Services; and the U.S. Army Medical Research and Development Command, Fort Detrick, Maryland, under contracts DAMD17-86-C-6229 and DAMD17-C-7218 (C.P.S.).
Grdina and Sigdestad, "Exhibit 1," (FIG. 1-Radiation Inactivation of Mammalian Cells).
Grdina, D.J., Y. Kataoka, I. Basic, and J. Perrin. The Radioprotector WR-2721 Reduces Neutron-Induced Mutations at the Hypoxanthine-Guanine Phosphoribosyl Transferase Locus in Mouse Splenocytes When Administered Prior to or Following Irradiation. Carcinogenesis, vol. 13, No. 5, pp. 811-814, 1992. (Supported in part by the U.S. Department of Energy, Office of Health and Environmental Research, under contract W-31-109-ENG-38; NIH/NCI CA-37435 and the Center for Radiation Therapy in Chicago, Illinois.).
Grdina, D.J., B.J. Wright, and B.A. Carnes. Protection by WR-151327 Against Late Effects Damage Induced by Fission-Spectrum Neutrons. Radiation Research, 128(S):124-127, 1991. (Supported in part by the U.S. Department of Energy, Office of Health and Environmental Research, under contract W-31-109-ENG-38; Center for Radiation Therapy and NIH-NCI grant CA-37435.).
Grdina, D.J., B. Nagy, C.K. Hill, R.L. Wells, and C. Peraino. The Radioprotector WR1065 Reduces Radiation-Induced Mutations at the HGPRT Locus in V79 Cells. Carcinogenesis, 6(6):929 931, 1985.
Grdina, D.J. and Meechan, P.J., "Effects of the Radioprotector WR-1065 on Normal Human Skin Fibroblast Cells in Culture," Radiation Research Meeting, Mar. 19-25, 1993.
Grdina, D.J., Constantinou, A., and Shigematsu, N., "Inhibition of Topoisomerase II Activity in Repair-Proficient CHO K1 Cells by WR-1065," Radiation Research Meeting, Mar. 19-25, 1993.
Held, K.D., "Models for Thiol Protection of DNA in Cells," Pharmac. Ther., 39:123-131, 1988. (Supported in part by PHS grants CA42167 awarded by the National Cancer Institute, DHHS).
Holmes, G.E., Bernstein, C., and Bernstein, H., "Oxidative and Other DNA Damages as the Basis of Aging: A Review," Mutation Research, 275:305-315, 1992.
Holwitt, E.A., oda, E, and Swenberg, C.E., "Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278," Radiation Research, 124:107-109, 1990.
Kataoka, Y., I. Basic J. Perrin, and D.J. Grdina. Anti-Mutagenic Effects of Radioprotector WR-2721 Against Fission-Spectrum Neutrons and .sup.60 Co -Rays in Mice, International Journal of Radiation Biology, #3, 61:387-392, 1992. (Supported in part by the U.S. Department of Energy, Office og Health and Environmental Research, under contract W-31-109-ENG-38; NIH/NCI CA-37435 and the Center for Radiation Therapy in Chicago, Illinois.).
Kataoka, Y., Shigematsu, N., O'Connor, T., Ward, W., and Grdina, D.J., "Captoril Protects Against Mutagenesis at the HPRT Locus in .sup.60 Co y-Ray-Irradiated CHO-AA8 Cells," Radiation Research Meeting, Mar. 19-25, 1993.
Kataoka, Y., Perrin, J., and Grdina, D.J., "Protection by WR2721 Against Fission-Neutron-Induced Mutagenesis in Mice".
Kirkwood, T.B.L., "DNA, Mutations, and Aging," Mutation Research, 219:1-7, 1989.
Linnane, A.W., Zhang, C., Baumer, A., and Nagley, P., "Mitochondrial DNA Mutation and the Ageing Process: Bioenergy and Pharmacological Intervention," Mutation Research, 275:195-208, 1992.
Livesy, Biochemical Pharmacology, 39 1807, 1990.
Mahoney, F., "Summary Statement," Radiation Study Section, Feb., 1986.
Maisin, J.R., Mattelin, G., and Lambiet-Collier, M., Chemical Protection Against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation, Radiation Research, 71:119-131, 1977.
Milas, L., Hunter, N., and Stephens, L.C., and Peters, L.J., :Inhibition of Radiation Carcinogenesis in Mice by S-2(3-Aminopropylamino)-Methylphosphorothioic Acid, Cancer Research, 44:5567-5569, Dec. 1984. (Supported in part by grants CA-06294 and CA-16672, provided by the National Cancer Institute Department of of Health and Human Services).
Minnunni, M., Wolleb, U., Mueller, O., Pfeifer, A., Aeschbacher, H.U., "Natural Antioxidants as Inhibitors of Oxygen Species Induced Mutagenicity," Mutation Research, 269:193-200, 1992. Ethanethiol Against Bleomycin, Nitrogen Mustard, Cis-Diamminedichloroplatinum, and Radiation Induced Mutagenicity in V-79 Cells, International Journal of Radiation Oncology, Biology, Physics, 12:1475 1478, Aug., 1986
Nagy, B., P.J. Dale, and D.J. Grdina. Protection Against Cis-Diammine-dichloroplatinum (II) Cytotoxicity and Mutagenicity in V79 Research, 46:1132 1135, Mar. 1986.
"1990 AACR Abstract F
ARCH Development Corporation
Degen Nancy
LandOfFree
Method for protection against genotoxic mutagenesis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for protection against genotoxic mutagenesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for protection against genotoxic mutagenesis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1947941