Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-01-07
1994-01-11
Hill, Jr., Robert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530399, A61K 3736
Patent
active
052781453
ABSTRACT:
The present invention relates to a method for protecting hematopoietic stem cells from the myelotoxicity of chemotherapeutic drugs or radiation therapy, which comprises, administering to a subject a therapeutically effective amount of transforming growth factor beta 1 for protecting bone marrow from the myelotoxicity of chemotherapeutic drugs or radiation therapy. The TGF.beta.1 may be administered prior (e.g. 24 hours) to the administration of the chemotherapeutic drugs or radiation therapy. Preferably, the TGF.beta.1 is administered to the subject in an amount of about 5 .mu.g to 25 .mu.g per kg body weight. The patient or subject of the present invention may be a mammal (e.g. human, domestic animal such as horse, cow, dog, cat or pig) and is preferably a human being. The mode of administration is either by interfemoral arterial, interperitoneally or subcutaneously, and preferably is by injection.
REFERENCES:
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Sing et al. "TGF--.beta. Selectively Inhibits Normal & Leukemic Human Bone Marrow Cell Growth In Vitro" Blood 5:1504-1511 (1988).
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Keller Jonathan R.
Ruscetti Francis W.
Wiltrout Robert
Cermak Shelly G.
Hill Jr. Robert J.
The United States of America as represented by the Department of
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