Method for prophylaxis and/or treatment of sickle cell disease

Details Method for prophylaxis and/or treatment of sickle cell disease Method for prophylaxis and/or treatment of sickle cell disease

1980-05-16

1981-04-14

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

A61K 3700

Patent

active

042619807

ABSTRACT:
Polypeptides which are useful in the prophylaxis and treatment of sickle cell disease are represented by the formula: ##STR1## wherein X is Val or Gln; Y is Pro or dehydroPro; Z is a residue of a basic amino acid with a side chain in the D-configuration; and A is a disulfide or monocarba radical, with the proviso that when X is Gln, Y is Pro and Z is D-Arg, then A is mono-carba.

REFERENCES:
Development of Therapeutic Agents for Sickle Cell Disease, INSERM Symposium No. 9, Rosa et al., 1979 Elsevier, North-Holland Biomed. Press, pp. 129-137.

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