Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-08-08
1999-06-22
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514505, 424655, A61K 3555
Patent
active
059143266
ABSTRACT:
A method for promoting weight and fat loss comprising administering to an individual in need thereof hydroxycitrate, carnitine and an agent which promotes the rapid intramitochondrial generation of oxaloacetate or induces endogenous production of pyruvate. This method also promotes an increase in lean body mass.
REFERENCES:
patent: 4548937 (1985-10-01), Stanko
patent: 5087623 (1992-02-01), Boynton et al.
Argaud, et al., Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated . . . , Eur. J. Biochem. 213:1341-1348 (1993).
Berry, et al., The Calorigenic Nature of Hepatic Ketogenesis: An Explanation for the Stimulation . . . , Eur. J. Biochem. 131:205-214 (1983).
Clarke, et al., Comparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics . . . , British Med. Jour. 2:1576-1578 (1977).
Conway, et al., A new approach for the estimation of body composition: infrared interactance, The Am. J. of Clin. Nutr. 40:1123-1130 (1984).
Cortez, et al., Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic . . . , The Am. J. of Clin. Nutr. 53:847-853 (1991).
Elia, et al., Evaluation of near infra-red interactance as a method for predicting body composition, Eur. J. of Clin. Nutr. 44:113-121 (1990).
Kaats, et al., Effects of Chromium Picolinate Supplementation on Body Composition: a Randomized, . . . , Curr. Thera. Res. 57(10):747-756 (1996).
Lee, et al., Metformin Decreases Food Consumption in Obese Non-Insulin-Dependent (NIDDM) Diabetics, Diabetes 4(Suppl.2) 170A.
Mabrouk, et al., Acute Hormonal Control of Acetyl-CoA Carboxylase, J. Biol. Chem. 265(11):6330-6338 (1990).
McCarty, M.F., Promotion of Hepatic Lipid Oxidation and Gluconeogenesis as a Strategy for Appetite Control, Medical Hypotheses 42:215-225 (1994).
McCarty, MF., Inhibition of Citrate Lyase May Aid Aerobic Endurance, Medical Hypotheses 45:247-254 (1995).
McGarry, et al., Role of carnitine in hepatic ketogenesis, Proc. Nat. Acad. Sci. USA 72(11):4385-4388 (1975).
McGarry, et al., Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production, Ann. Rev. Biochem. 49:395-420 (1980).
Pegorier, et al., Induction of ketogenesis and fatty acid oxidation by glucagon and cyclic AMP in cultured . . . , Biochem. J. 264:93-100 (1989).
Stanko, et al., Inhibition of Lipid Accumulation and Enhancement of Energy Expenditure by the Addition . . . , Metabolism, 35(2):182-186 (1986).
Stanko, et al., Reduction of Carcass Fat in Swine with Dietary Addition of Dihydroxyacetone and Pyruvate, J. Anim. Sci 67:1272-1278 (1989).
Stanko, et al., Body composition, energy utilization, and nitrogen metabolism with a severely . . . , Am. J. Clin. Nutr. 55:771-776 (1992).
Stanko, et al., Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d . . . , Am. J. Clin. Nutr. 56:630-635 (1992).
Stanko, et al., Pyruvate supplementation of a low-cholesterol, low-fat diet: effects on plasma lipid . . . , Am. J. Clin. Nutr. 59:423-427 (1994).
Stanko, et al., Inhibition of regain in body weight and fat with addition of 3-carbon compounds to the diet . . . , Inter. J. Obesity 20:925-930 (1996).
Stumvoll, et al., Metabolica Effects of Metformin in Non-Insulin-Dependent Diabetes Mellitus, N. Engl. J. Med. 333(9):550-554 (1995).
Gustin John
McCarty Mark F.
Ambi Inc.
Krass Frederick
LandOfFree
Method for promoting weight and fat loss does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for promoting weight and fat loss, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for promoting weight and fat loss will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1708251