Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-10-10
2006-10-10
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C435S325000, C435S372000, C435S375000, C530S329000, C530S330000
Reexamination Certificate
active
07118748
ABSTRACT:
The present invention provides methods, improved cell culture medium and kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of angiotensinogen, angiotensin I (Al), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2type 2 receptor agonists, either alone or in combination with other growth factors and cytokines.
REFERENCES:
patent: 6335195 (2002-01-01), Rodgers et al.
Smilek et al. PNAS (199) 88:9633-9637.
Mrug et al., “Angiotensin II facilitates EPO-mediated Proliferation of Early Erythroid Progenitors” Blood 88:64a (1996)Abstract 2574.
diZerega Gere S.
Rodgers Kathleen E.
Belyavskyi Michail A.
Chan Christina
McDonnell Boehnen & Hulbert & Berghoff LLP
University of Southern California
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