Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Catalytic antibody
Patent
1995-06-07
1999-07-06
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Catalytic antibody
435 76, C12N 900
Patent
active
059196815
ABSTRACT:
The invention is directed to a method for generating novel catalysts, particularly high turnover rate enzymes or biocatalysts. Functional catalytic units may be integrated into the germline composition of an animal in order to generate such novel catalysts.
REFERENCES:
patent: 4792446 (1988-12-01), Kim et al.
patent: 4963355 (1990-10-01), Kim et al.
patent: 5037750 (1991-08-01), Schochetman et al.
patent: 5156965 (1992-10-01), Schochetman et al.
patent: 5318897 (1994-06-01), Paul
patent: 5401641 (1995-03-01), Kim et al.
Green, N. S., et. al. (1998) BioEssays 20, 227-234.
Oliphant, A. R., et. al. (1989) Proc. Natl. Acad. Sci., USA 86, 9094-9098.
Green, L.L., et. al. (1994) Nature Genetics 7, 13-21.
Lonberg, N., et. al. (1994) Nature 368, 856-859.
Wedemayer, G. J., et. al. (1997) J. Mol. Biol. 268, 390-400.
Sun, M., et. al. (1997) J. Mol. Biol. 271, 374-365.
DeSutter, K, et. al. (1994) Mol. Immun. 31(4), 261-267.
Rosenthal, D., et. al. (1994) Biochem. Biophys. Res. Comm. 202(2), 880-887.
Titmas et al., "Aspects of Antibody-Catalyzed Primary Amide Hydrolysis," Applied Biochemistry and Biotechnology, 1994, vol. 47, pp. 277-290.
Suzuki, H. "Recent Advances in Abzyme Studies," J. Biochem., 1994, vol. 115, No. 4, pp. 623-628.
Smiley et al., "Selection of catalytic antibodies for a biosynthetic reaction from a combinatorial cDNA library by complementation of an auxotrophic Escherichi coli: Antibodies for orotate decarboxylation," Proc. Natl. Acad. Sci. USA, 1994, vol. 91, No. 18, pp. 8319-8323.
Janda, et al., "Direct selection for a catalytic mechanism from combinatorial antibody libraries," Proc. Natl. Acad. Sci. USA, 1994, vol. 91, No. 7, pp. 2532-2536.
Taylor, et al., "A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins," Nucleic Acids Research, 1992, vol. 20, No. 23, 6287-6295.
Sarvetnick, et al., "Increasing the chemical potential of the germ-line antibody repertoire," Proc. Natl. Acad. Sci. USA, 1993, vol. 90, No. 9, pp. 4008-4011.
Thorn, et al., "Large rate accelerations in antibody catalysis by strategic use of haptenic charge," Nature, 1995, vol. 373, No. 6511, pp. 228-230.
LandOfFree
Method for promoting enzyme diversity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for promoting enzyme diversity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for promoting enzyme diversity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-898598