Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1995-03-27
1997-10-28
Elliott, George G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
4351723, 435368, C12N 508, C12N 1509, C12Q 102
Patent
active
056817118
ABSTRACT:
A method for determining whether a compound inhibits apoptosis induction in neural cells expressing a FALS-associated sod-1 mutant. A neural cell culture is provided having a plurality of neural cells expressing a FALS-associated sod-1 mutant, wherein through the expression of the sod-1 mutant, the neural cells have a low resistance to apoptosis induction. The neural cell culture is treated with a substance to form a modified cell culture and apoptosis is induced in the modified cell culture. The modified cell culture is then assayed to determine whether it has a higher resistance to apoptosis induction than the untreated neural cell culture. The method is useful in screening substances for use as potential drugs for treating ALS.
REFERENCES:
Zhong et al., "bcl-2 Inhibits Death of Central Neural Cells Induced by Multiple Agents", Proceedings of the National Academy of Sciences USA, vol. 90, pp. 4533-4537, May 1993.
Borchelt et al., "Superoxide Dismutase 1 With Mutations Linked to Familial Amyotrophic Lateral Sclerosis Possesses Significant Activity", Proceedings of the National Academy of Sciences USA, vol. 91, pp. 8292-8296, Aug. 1994.
Gurney et al., "Motor Neuron Degeneration in Mice That Express a Human Cu,Zn Superoxide Dismutase Mutation", Science, vol. 264, pp. 1772-1775, Jun. 17, 1994.
Elliott George G.
Nelson Amy J.
Reiter Stephen E.
University of California-Los Angeles
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