Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-06-07
1999-08-24
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241331, 4241341, 4241411, 4241431, 4241441, 4241531, 4241731, 4241851, 42419511, 514 2, 514 8, 514885, 530350, 5303871, 5303873, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875, A61K 39395, A61K 3817, A61K 3512
Patent
active
059422297
ABSTRACT:
Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which mediates contact-dependent helper effector functions. In a preferred embodiment, the antagonist is an antagonist of gp39. Primary and secondary humoral immune responses can be suppressed and suppression is prolonged.
REFERENCES:
patent: 5474771 (1995-12-01), Lederman et al.
Scaria et al. Gene Therapy 4: 611-617 (1997).
Datja Arthristis and Rheumatism 40: 1735-1745 (1997).
Allen et al. (1993) "CD40 Ligand Gene Defects Responsible for X-linked Hyper-lgM Syndrome" Science 259:990-993.
Armitage et al. (1992) "Molecular and biological characterization of a murine ligand for CD40" Nature 357:80-82.
Aruffo et al. (1990) "CD44 Is the Principal Cell Surface Receptor for Hyaluronate" Cell 61:1303-1313.
Aruffo et al. (1993) "The CD40 Ligand, gp39, Is Defective in Activated T Cells from from Patients with X-Linked Hyper-lgM Syndrome" Cell 72: 291-300.
Bartlett et al. (1990) "Cognate Interactions Between Helper T Cells and B Cells" J. Immunol. 145(12):3956-3962.
Chatterjee et al. (1994) "Idiotypic antibody immunotherapy of cancer" Cancer Immunol. Immunother. 38:75-82.
Dillman et al. (1989) "Monoclonal Antibodies for Treating Cancer" Annals of Internal Medicine 111(7): 592-603.
DiSanto et al. (1993) "CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM" Nature 361:541-543.
Fanslow et al. (1992) "Soluble Forms of CD40 Inhibit Biologic Responses of Human B Cells" Journal of Immunology 149(2):655-660.
Fitch et al. (1993) "Cell Mediated Immune Regulation" Fundamental Immunology, 3rd Ed., William E. Paul (ed.) (New York: Raven Press Ltd.) Chp. 13:733, 735-737.
Foy et al. (1994) "gp39-CD40 Interactions Are Essential for Germinal Center Formation and Development of B Cell Memory" J. Exp. Med. 180: 157-163.
Foy et al. (1993) "In Vivo CD40-gp39 Interactions Are Essential for Thymus-dependent Humoral Immunity. II. Prolonged Suppression of the Hormoral Immune Response by an Antibody to the Ligand for CD40, gp39" J. Exp. Med. 178:1567-1575.
Harris et al. (1993) "Therapeutic antibodies--the coming of age" Tibech 11:42-44.
Hodgkin et al. (1990) "Separation of Events Mediating B Cell Proliferation and Ig Production By Using T Cell Membranes and Lymphokines" J. Immunol. 145(7):2025-2034.
Hollenbaugh et al. (1992) "The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity" EMBO Journal 11(12):4313-4321.
Korthauer et al. (1993) "Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM" Nature 361:539-541.
Lane et al. (1992) "Activated human T cells express a ligand for the human B cell-associated antigen CD40 which particpates in T-cell-dependent activation of B lymphocytes" Eur. J. Immunol. 22:2573-2578.
Lederman et al (1992) "Identification of a Novel Surface Protein on Activated CD4.sup.+ T Cells that Induces Contact-dependent B cell Differentiation (Help)" J. Exp. Med. 175: 1091-1101.
Lederman et al. (1992) "Molecular Interactions Mediating T-B Lymphocyte collaboration in Human Lymphoid Follicle" J. Immunol. 149(12):3817-3826.
Marshall et al. (1993) "The Molecular Basis for T Cell Help in Humoral Immunity: CD40 and Its Ligand, gp39" J. Clin. Immunol. 13(3): 165-174.
Mountain and Adair (1992) "Engineering Antibodies for Therapy" Biotechnology and Genetic Engineering Reviews 10:1, 10-13.
Noelle and Snow (1992) "T helper cells" Curr. Opin. Immunol 4:333-337.
Noelle et al. (1992) "A 39-kDa protein on activated helper T cells binds CD40 and Transduces the signal for cognate activation of B cells" PNAS USA 89:6550-6554.
Noelle et al. (1992) "CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation" Immunology Today 13:431-433.
Nossal (1989) "Immunologic Tolerance" in Fundamental Immunology, William E. Paul (ed.) (New York: Raven Press Ltd.) Chp. 19: 571-586.
Paulie et al. (1989) "The Human B Lymphocyte and Carcinoma Antigen, CDw40, is a Phosphoprotien Involved in Growth Signal Transduction" J. Immunol. 142: 590:595.
Spriggs et al. (1992) "Recombinant Human CD40 Ligand Stimulates B Cell Proliferation and Immunoglobulin E Secretion" J. Exp. Med. 176: 1543-1550.
Stamenkovic et al. (1989) "A B-lymphocyte activation molecule related to the nerve growth factor recptor and induced by cytokines in carcinomas" EMBO Journal 8(5):1403-1410.
Teale and Klinman (1984) "Control of the Production of Different Classes of Antibody" in Fundamental Immunology, William E. Paul (ed.) (New York: Raven Press Ltd.) Chp. 19:519-535.
Tueveson (1993) "New Immunosuppressants: Testing and Development in Animal Models and the Clinic: with Special Reference to DSG" Immunological Reviews 136:99-109.
Waldmann (1992) "Immune Receptors: Targets for Therapy of Leukemia/Lymphoma, Autoimmune Diseases and for the Preventiaon of Allograft Rejection" Ann. Rev. Immunol. 10:675-704.
Waldmann et al. (1991) "Monoclonal Antibodies in Diagnosis and Diagnosis and Therapy" Science 52:1657-1662.
Yellin et al. (1991) "A Human CD4-T Cell Leukemia Subclone with Contact-dependent Helper Function" J. Immunol. 147:3389-3395.
Gray et al. J. Exp Med 180: 141-155 (1994).
Stuber et al. J Exp Med. 183: 693-698 (1996).
Biacone et al. Kidney Intl. 48: 458-468 (1995).
Larsen et al. Transplantation 61: 4-9 (1996).
Rosen et al. Dictionary of Immunology Stockton Press NY NY 1989, p. 210 only.
Foy Teresa M.
Noelle Randolph J.
Chan Christina Y.
Gambel Phillip
Trustees of Dartmouth College
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