Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Reexamination Certificate
2006-10-03
2006-10-03
Witherspoon, Sikarl A. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
C568S825000, C568S668000
Reexamination Certificate
active
07115786
ABSTRACT:
The present invention relates to a method of reacting (3R,3′R,6′R)-lutein with a catalytic amount of an acid to obtain a mixture of anhydroluteins, rich in anhydrolutein III, with substantially no Z-isomers being formed. The mixture is converted to (3R)-β-cryptoxanthin (major product) and (3R,6′R)-α-cryptoxanthin (minor product) by reacting the anhydroluteins with borane-amine complexes (e.g. Me3N.BH3) or other hydride donors and an acid in a chlorinated solvent, preferably dichloromethane, at ambient temperature to produce (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin.
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Sterne Kessler Goldstein & Fox P.L.L.C.
University of Maryland College Park
Witherspoon Sikarl A.
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