Method for production of T-butyl 3-oxobutyrates and their use

Details Method for production of T-butyl 3-oxobutyrates and their use Method for production of T-butyl 3-oxobutyrates and their use

1991-10-03

1993-02-02

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

540222, 540225, 540227, C07C 6746

Patent

active

051839296

ABSTRACT:
Disclosed are an advantageous method of industrial production of tert-butyl 3-oxobutylate, which is a useful intermediate for synthesis, characterized by reacting tert-butyl alcohol with diketene in the presence of 4-(tertiary amino) pyridine, and an industrially advantageous method of producing cephalosporin compounds or pharmaceutically acceptable salts thereof, using tert-butyl 3-oxobutylate as an intermediate.

REFERENCES:
patent: 4399132 (1983-08-01), Curran et al.
Sven-Olov Lawesson et al., "Acetoacetic Acid, Tert-butyl Ester", Organic Syntheses, vol. 42, (1962) pp. 28-29.
Stephen R. Wilson et al., "The Ester Enolate Carroll Rearrangement", J. Org. Chem., vol. 49, (1984), pp. 722-725.

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