Method for production of shaped body for treating wounds in...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

Reexamination Certificate

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C424S486000

Reexamination Certificate

active

07541047

ABSTRACT:
Water-dispersible or water-soluble polymers, particularly those of the family of compounds comprising the poloxamers or the polyesters or amphiphilic agents (emulsifiers), and also lipophilic materials are dispersed by melting the components at suitable temperatures with admixture of pharmaceutically active substances by mechanical precedures, i.e. a lipophilic dispers phase is distributed in a hydrophilic continuous polymer phase to form a stable dispersion. By controlled cooling, curing, and storage followed by high-pressure molding at defined temperatures and operating pressures there are produced, in addition to other types of shaped bodies, dispersed polymeric fatty sticks distinguished by particularly good fracture strength, flexibility, and variable time-specific dimensional stability.

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G. Regdon, Jr., et al., “Formulation and in vitro study of theophylline containing suppositories”, XP 000582508, 996 Die Pharmazi, 51 (1996) May, No. 5 Eschborn, DE, pp. 347-352.

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