Method for production of radiopharmaceuticals using ultrasound

Details Method for production of radiopharmaceuticals using ultrasound Method for production of radiopharmaceuticals using ultrasound

1987-06-17

1990-06-12

Terapane, John F.

Chemistry: electrical and wave energy

Processes and products

Processes of treating materials by wave energy

534 14, 424 11, B01J 1910, C07F 1300, A61K 4902

Patent

active

049330551

ABSTRACT:
A novel method for the production of bis(arene) technetium radiodiagnostic imaging agents is herein disclosed. The method consists of employing Fischer synthesis reactants in an ultrasonic bath. The products are virtually pure, thus lacking the severe degree of disproportionation which routinely occurs when partially alkylated bis(arene)technetium compounds are produced by thermally driven reactions.

REFERENCES:
patent: 4466870 (1984-08-01), Boudjouk et al.
patent: 4526724 (1985-07-01), Pillsbury
European Journal of Nuclear Medicine, vol. 11, pp. 361-362, 1986.

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