Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Reexamination Certificate
2006-06-27
2006-06-27
Lilling, Herbert J. (Department: 1651)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
C435S075000, C435S135000, C435S146000, C435S148000
Reexamination Certificate
active
07067290
ABSTRACT:
A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to a value conducive to polyketide product stability, continuing the fermentation until a maximal titer of polyketide is achieved, and optionally extracting the polyketide from the culture.
REFERENCES:
patent: 5712146 (1998-01-01), Khosla et al.
patent: 5830750 (1998-11-01), Khosla et al.
patent: 5962290 (1999-10-01), Khosla et al.
patent: 6033883 (2000-03-01), Barr et al.
patent: 6080555 (2000-06-01), Khosla et al.
patent: 6177262 (2001-01-01), Ziermann et al.
patent: 6261816 (2001-07-01), Khosla et al.
patent: 6274560 (2001-08-01), Khosla et al.
patent: 6451768 (2002-09-01), Chu
patent: 6461838 (2002-10-01), Khosla et al.
patent: 6509455 (2003-01-01), Ashley et al.
patent: 6551802 (2003-04-01), Khosla et al.
patent: 6558942 (2003-05-01), Khosla et al.
patent: 6562602 (2003-05-01), Licari et al.
patent: 2002/0045220 (2002-04-01), Khosla et al.
patent: 2002/0119937 (2002-08-01), Khosla et al.
patent: 2002/0137152 (2002-09-01), Santi et al.
patent: 2004/0014183 (2004-01-01), Licari et al.
patent: 2004/0018598 (2004-01-01), Santi et al.
patent: WO 00/44717 (2000-08-01), None
patent: WO 01/31035 (2001-05-01), None
patent: WO 01/31049 (2001-05-01), None
patent: WO 02/12534 (2002-02-01), None
Cortes et al., “Repositioning of a Domain in a Modular Polyketide Synthase to Promote Specific Chain Cleavage,” Science 268, 1487-1489 (1995).
Raganathan et al., “Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues,” Chem. Biol 6, 731-741 (1999).
Leaf et al., “Employing racemic precursors in directed biosynthesis of 6-dEB analogs,” J. Chem. Technol. Biotechnol. 77, 1122-1126 (2002).
Kao et al., “Evidence for Two Catalytically Independent Clusters of Active Sites in a Functional Modular Polyketide Synthase,” Biochemistry, 35, 12363-12368 (1996).
Hu et al., “Enhanced heterologous polyketide production inStreptomycesby exploiting plasmid co-integration,” J. Ind. Microbiol. Biotechnol., 30 (8), 516-522 (2003).
Gokhale et al., “Dissecting and Exploiting intermodular Communication in Polyketide Synthases,” Science, 284, 482-485 (1999).
McDaniels et al., “Engineered Biosynthesis of Novel Polyketides,” Science, 262, 1546-1550 (1993).
Kieser et al., Practical Streptomyces Genetics, p. 153 (John Innes Foundation, Norwich, UK, 2000).
Kao et al., “Manipulation of Macrolide Ring Size by Directed Mutagenesis of a Modular Polyketide Synthase,” J. Am. Chem. Soc., 117, 9105-9106 (1995).
Weissman et al., “Evaluating precursor-directed biosynthesis towards novel erythromycins throughin vitrostudies on a bimodular polyketide synthase,” Chem. Biol. 5, 743-754 (1998).
Regentin et al., “Precursor-directed biosynthesis of novel triketide lactones,”Biotechnol Prog.20 (1), 122-7 (Jan.-Feb. 2004).
Desai Ruchir P.
Regentin Rika
Chao Yuan
Kosan Biosciences Incorporated
Lilling Herbert J.
LandOfFree
Method for production of polyketides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for production of polyketides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for production of polyketides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3621502