Method for production of mycophenolic acid by fermentation

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435123, 4351721, 435934, 735 68, C12P 1704, C12P 1702, C12N 1500, C12R 181

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044528914

ABSTRACT:
Mycophenolic acid is produced by aerobically culturing in a culture medium a mutant of the genus Penicillium capable of producing mycophenolic acid, said mutant being resistant to clofibrat, and recovering the mycophenolic acid which accumulates in the culture medium.

REFERENCES:
patent: 4115197 (1978-09-01), Queener et al.
Birch, "Biosynthesis of some Monobenzenoid Quinones" Ciba Foundation Symposium, Quinones Electron Transport 1960 pp. 233-243 Chem. Abstracts 56: 9220i.
Cohen et al, "Effects of Clofibrate on Sterol Metabolism in the Rat" Biochemica et Biophysica Acta 369 (1974) pp. 79-85.
Andressen et al, "Nicotinamide-Adenine Dinucleotide Phosphate Dependant Formate Kehydrogenase from Clostridium Thermoaceticum" Journal of Bacteriology 120(1) (1974) pp. 6-14 Chemical Abstracts 81: 165365h.
Van Dijk et al, "Purification and Properties of Hydrogenase from Megasphaera Elsdenii" European Journal of Biochemistry 102(2) (1979) pp. 317-330 Chem. Abstracts 92: 89805m.

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