Method for production of kanamycin C and its derivatives

Details Method for production of kanamycin C and its derivatives Method for production of kanamycin C and its derivatives

1977-05-23

1978-10-17

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 10, 536 17, A61K 3171, C07H 1522

Patent

active

041209559

ABSTRACT:
Kanamycin C, 3'-deoxykanamycin C and 3'4'-dideoxykanamycin C are obtained by a new process comprising treating the primary 6'-amino group of a tetra-N-protected derivative of kanamycin B, 3'-deoxykanamycin B and 3', 4'-dideoxykanamycin B with a nitrite to convert said amino group into hydroxyl group and then removing the protective groups. 3'-Deoxykanamycin C and 3', 4'-dideoxykanamycin C are new semi-synthetic aminoglycosidic antibiotics.

REFERENCES:
patent: 3929762 (1975-12-01), Umezawa et al.
Tipson et al., "Advances in Carbohydrate Chem. and Biochemistry," vol. 30, 1974, Academic Press, N. Y. pp. 183-189.

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