Method for production of dimeric alkaloids

Details Method for production of dimeric alkaloids Method for production of dimeric alkaloids

1989-08-08

1991-08-06

Rivers, Diana

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

546 51, C07D51904

Patent

active

050379771

ABSTRACT:
This invention concerns a method for the production of dimeric alkaloids, characterized by reacting of catharanthine with vindoline in the presence of Fe.sup.3+ and (1) removing or inactivating the Fe.sup.3+ and allowing the reaction product to react with a reducing agent or (2) allowing presence of oxygen and a dicarboxylic acid or a derivative thereof in the reaction system and allowing the reaction product to react with a hydride source.
In accordance with this invention, such dimeric alkaloid as vinblastine, leurosidin, and 3',4'-anhydrovinblastine which are useful as antineoplastic drugs can be produced in high yields.

REFERENCES:
patent: 4279817 (1981-07-01), Kutney
patent: 4737586 (1988-04-01), Potier et al.
patent: 4778885 (1988-10-01), Vukovic et al.

Affiliated with

Also associated with

Rating

Method for production of dimeric alkaloids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for production of dimeric alkaloids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for production of dimeric alkaloids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1988591