Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-08-18
1989-01-31
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540222, 540225, 540226, C07D50136, A61K 31545
Patent
active
048017035
ABSTRACT:
A novel method of producing a cephalosporin compound of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or an acyl group; R is a hydrogen atom or an ester residue; the dotted line means a double bond in 2- or 3-position of the cephem ring; and R.sup.4 is a nucleophilic compound residue, or a salt thereof, directedly in one step from a compound of the formula ##STR2## wherein R.sup.1, R and the dotted line have the meanings defined above, or a salt thereof, by reacting in the presence of an organic solvent the compound [II] or a salt thereof, a nucleophilic compound or a salt thereof, and (1) a trivalent or pentavalent cyclic phosphorus compound having a partial structure of the formula ##STR3## wherein W is an oxygen atom, a sulfur atom or NR.sup.2 ; W.sup.1 is an oxygen atom, a sulfur atom or NR.sup.3 ; and R.sup.2 and R.sup.3 may be the same or different and each means a hydrogen atom or a hydrocarbon group, or a salt thereof, or (2) a reaction product of a compound having a partial structure of the formula ##STR4## wherein W and W.sup.1 have the same meaning as defined above, or a salt thereof, with a phosphorus oxyhalide, trihalide or pentahalide.
REFERENCES:
patent: 4317907 (1982-02-01), Saikawa et al.
Takeda Chemical Ind KK, Central Patents Index, Basic Abstracts Journal, J5 3024-592, Jun. 14, 1978.
Kato Masayasu
Naito Kenzo
Tsukamura Kazuo
Rizzo Nicholas S.
Takeda Chemical Industries Ltd.
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