Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1992-02-14
1993-06-29
Lacey, David L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
435 701, 5303893, 53038825, C12P 2108, C07K 1500, C07K 1528
Patent
active
052234100
ABSTRACT:
The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized antigen free animal. The invention also provides a method for the use of such monoclonal antibodies, and polyclonal antibodies derived from an immunized antigen free animal, for in vitro and in vivo clinical diagnostics and therapeutics. Also, the subject invention provides a fibrin-specific monoclonal antibody.
REFERENCES:
Wostman, B. S., Ed., Gnotobiotes: Standards and Guidelines The Breeding, Care, and Management of Laboratory Animals, National Research Counsel, National Academy of Sciences, Washington, D.C., (1970).
Pleasants, J. R. et al., Journal Nutrition, Adequacy of Chemically Defined, Water-Soluble Diet for Germfree BALB/C Mice through Successive Generations and Litters 116, 1949-1964 (1986).
Hooijkaas, H. et al., Journal of Immunology, 134,2223-2227 (1985), Frequency Analysis of Functional Immunoglobulan C- and V-Gene Expression by Mitogen Reactive B Cells and Germfree Mice Fed Chemically Defined Ultra-Filtered "Antigen Free" Diet.
Hoojikaas, H. et al., Germfree Research: Microflora Control and its Application to the Biomedical Sciences, 359-362 (1985), Isotype Expression and Specificity Repertoire of Lipopolysaccharide-Reactive B Cells in Germfree Mice Fed Chemically Defined Ultrafiltered Antigen Free Diet.
Suter, M. et al., Infection and Immunity, 49, 615-620 (1985) Stimulation of Immunoglobulin Containing Cells and Isotype-Specific Antibody Response in Experimental Mycoplasma hyponeumoniae Infection in Specific Pathogen-Free Pigs.
Umehara, K. et al., Germfree Research: Microflora Control and its Application to the Biomedical Sciences, 351-353 (1985), The Effect of the Antigenic Stimuli Derived from the Diet in Microbial Flora on Immunoglobulin Levels.
Wostmann, B. et al., Ed., Germfree Research Micro-flora Control and its Applications to the Biomedical Sciences, Allan Liss, Publisher, New York, (1984).
Bos, N. A. et al., Cellular Immunology, 105, 235-245 (1987), Early Development of Ig-Secreting Cells in Young of Germfree BALB/C Mice Fed A Chemically Defined Ultrafiltered diet.
Hooijakaas, H. et al., Germfree Research: Microflora Control and its Application to the Biomedical Sciences, 355-358 (1985), Isotype Distribution and Specificity Repertoire of "Spontaneously" occurring (Background) Immunoglobulin-Secreting Cells and Germfree Mice Fed Chemically Defined Ultrafiltered Antigen-free Diet.
Suzuki, T. et al., Germfree Research: Microflora Control and its Application to the Biomedical sciences, 325-328 (1985), Immunoresponses and Natural Killer Activity of Nude and Normal Mice Under Conventional and Germfree Conditions.
Pleasants, J., C.R.C. Handbook of Immunology in Aging, 257-297, (1981), The Germfree System for Aging and Immunity.
Sasaki, S., Germfree Research: Microflora Control and its Application to the Biomedical Sciences, 9-15 (1985), The Present Status of Clinical Applications of Germfree Technology.
Trexler, P., Germfree Research: Microflora Control and its Application to the Biomedical Sciences, 3-7, (1985), The Evolution of Gnotobiotic Technology.
Gustafsson B., Germfree Research: Microflora Control and its Application to the Biomedical Sciences, 17-23, (1985), The Future of Germfree Research.
Bos, N. A., et al., Cellular Immunology, 112, 371-380 (1988), The Influence of Exogenous Antigenic Stimulation on the Specificity Repertoire of Background Immunoglobulin-Secreting Cells of Different Isotypes.
Stepankova, R. et al., Folia Microbiol., 30, 291-294 (1985), Immunoglobulin-Producing Cells in Lymphatic Tissues of Germfree and Conventional Rabbits as Detected by an Immunofluorescence Method.
Bos, N. A., et al., Journal of Reproductive Immunology, 9, 237-246, "Background" Ig-Secreting Cells in Pregnant Germfree Mice Fed a Chemically Defined Ultrafiltered Diet.
Pleasants, J. R., et al., S. Sasaki et al. (eds), Recent Advances in Germfree Research, pp. 535-538, Tokai University Press (1981), entitled: Immune Response of Germfree C3H Mice Fed Chemically Defined Ultrafiltered "Antigen-Free" Diet.
Olson, G. et al., The Journal of Immunology, 97, 275286 (1966), Cellular and Humoral Immune Response of Germfree Mice Stimulated with 75 HGG or Salmonella typhimurium.
Ohwake, M., et al., Immunology, 32, 43-48 (1977) A Comparative Study on the Humoral Immune Response in Germ-free and Conventional Mice.
Umehara, K., et al., S. Sasaki (eds.) Recent Advances in Germfree Research, pp. 453-457, Tokai University Press (1981), Enteric Adenovirus Infection of Germfree Mice Reared on an Antigen-Free Diet.
Coates, M., et al. (Eds.), The Germ-Free Animal in Biomedical Research (1984) London, pp. 335-384.
Underwood et al. Clin. exp. Immunol. 60:417-426 (1985) Hybrids From Normal Germfree, Nude and Neonatal Mice Produce Monoclonal Auto Antiboidies to Eight Different Intracellular Structures.
Kohler, G. and Milstein, C. Eur. J. Immun. 6:511-519 (1976) Derivation of Specific Antibody-Producing Tissue Culture and Tumor Lines by Cell Fusion.
Gargan Paul E.
Pleasants Julian R.
Ploplis Victoria A.
American Biogenetic Sciences Inc.
Futrovsky Susan L.
Lacey David L.
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