Method for producing water dispersible sterol formulations

Details Method for producing water dispersible sterol formulations Method for producing water dispersible sterol formulations

1998-02-19

2000-08-29

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424400, 424439, 424464, 424489, 424500, 424501, A61K 900, A61K 4700, A61K 920, A61K 914, A61K 950

Patent

active

061105023

ABSTRACT:
A method for preparing .beta.-sitosterol is disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the .beta.-sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.

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Sjostrom, B. et al: "A Method for the Preparation of Submicron Particles of Sparingly Water-soluble Drugs by Precipitation in Oil-in-Water Emulsions II: Influence of the Emulsifier, the Solvent, and the Drug Substance", Journal of Pharmacuetical Sciences, vol. 82, No. 6, Jun. 1, 1993, pp. 584-589.
T. Heinemann et al., "Mechanisms of Action of Plant Sterols on Inhibition of Cholesterol Absorption," Eur. J. Clin. Pharmacol (1991) 40 [Suppl 1]: pp. 59-63.

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