Method for producing tripdiolide, triptolide and celastrol

Details Method for producing tripdiolide, triptolide and celastrol Method for producing tripdiolide, triptolide and celastrol

1980-07-02

1982-05-04

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435127, 435240, 435241, 424279, 424317, C12N 500, C12N 1500

Patent

active

043283098

ABSTRACT:
A process for the production of tripdiolide, triptolide and celastrol comprises the steps of:
(a) preparing a cellular inoculum from Tripterygium wilfordii Hook F;
(b) inoculating a nutrient growth medium with the cellular inoculum and incubating the inoculated growth medium at 20.degree.-30.degree. C. for up to 8 weeks to produce a cellular product;
(c) harvesting the cellular product from the inoculated growth medium; and
(d) isolating tripdiolide, triptolide and celastrol from the cellular product and supernatant inoculated growth medium.

REFERENCES:
patent: 4005108 (1977-01-01), Kupchan et al.
Reynolds et al., "Plant Cell Lines", Methods in Enzymology, vol. LVIII, Academic Press, New York, 478-486, (1979).
Bergmann, "Plating of Plant Cells", Plant Tissue Culture and Its Bio-Technological Application, Springer-Verlag, New York, 213, 218, (1977).
Schechter et al., J.A.C.S., 64, 182-183, (1942).
Monache et al., J.C.S. Perkin I, 3127-3131, (1979).

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