Method for producing trifluoro-3(r)-hydroxybutyric acid...

Details Method for producing trifluoro-3(r)-hydroxybutyric acid... Method for producing trifluoro-3(r)-hydroxybutyric acid...

2005-05-17

2005-05-17

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C435S134000, C435S148000, C435S189000, C435S320100, C435S136000, C435S155000

Reexamination Certificate

active

06893861

ABSTRACT:
The invention relates to a biotechnological method for producing trifluoro-3(R)-hydroxybutyric acid derivatives of the general formula (I), where R1represents —OR2, where R2is hydrogen, C1-10alkyl, C1-10alkenyl, C3-8cy-cloalkyl, aryl, alkoxyalkyl or alkoxyalkoxyalkyl; —NR3R4, where R3and R4are the same or different and represent hydrogen, C1-10alkyl, C1-10alkenyl, C3-8cycloalkyl or aryl; or —SR5, where R5represents hydrogen, C1-10alkyl, C1-10alkenyl, aryl or C3-8cycloalkyl, based on a trifluoroacetoacetic acid derivative of the general formula (II), where R1has the meaning given above, by means of micro-organisms which are able to reduce a carbonyl function or by means of a cell-free enzyme extract of said micro-organisms.

REFERENCES:
patent: 5523223 (1996-06-01), Kula et al.
patent: 000736606 (1996-10-01), None
Kita et al., Appl. Environm. Microbiol., 63:2303-2310.

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