Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing hydrocarbon
Patent
1989-08-29
1991-02-19
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing hydrocarbon
435171, 435254, 435929, C12R 177, C12P 500
Patent
active
049943839
ABSTRACT:
Mutants blocked or altered in the production of the trichothecene mycotoxin T-2 have been selected following UV mutagenesis of Fusarium sporotrichioides NRRL 3299. One mutant, NRRL 18339, accumulates the rare trichothecenes dideacetylcalonectrin and deacetylcalonectrin. The second mutant, NRRL 18340, accumulates trichodiene, the first intermediate on the trichothecene biosynthetic pathway. These compounds are useful toxins or toxic precursors for the production of or investigation of immunotoxins for cancer therapy.
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Beremand Marian N.
Black Patricia J.
Fado John D.
Lilling Herbert J.
Ribando Curtis P.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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