Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1988-05-10
1991-06-04
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435254, 435929, 435244, C12P 1718, C12N 114, C12N 138
Patent
active
050213431
ABSTRACT:
Addition of L-leucine ot the fermentation medium of Fusarium mutant NRRL 18365 increases the production of the trichothecenes neosolaniol, 8-propionyl-neosolaniol, and 8-isobutyryl-neosolaniol. These materials are useful as toxins for the production of or investigation of immunotoxins for cancer therapy.
REFERENCES:
Bergers et al., Appl. Environ. Microbiol., vol. 50, pp. 656-662, 1985.
Ueno et al., Appl. Microbiol., vol. 30, pp. 4-9, 1975.
Beremand, Appl. Environ. Microbiol, vol. 53, pp. 1855-1859, 1987.
Stanbury et al., "Principles of Fermentation Technology", Pergamon Press, 1984, pp. 35-58.
Y. Ueno et al., "Biological and Chemical Detection of Trichothecene Mycotoxins of Fursarium Species", Appl. Microbiol. 25(4): 699-704, (Apr. 1973).
M. N. Beremand et al., "Effect of Leucine Auxotrophy on T-2 Toxin Biosynthesis: Production of Novel End-Products", Abstracts of Yeast Genetics and Molecular Biology, p. 93 (1986).
Beremand Marian N.
Plattner Ronald D.
VanMiddlesworth Frank L.
Fado John D.
Marx Irene
Ribando Curtis P.
Robinson Douglas W.
Silverstein M. Howard
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