Method for producing thrombolytic preparation

Details Method for producing thrombolytic preparation Method for producing thrombolytic preparation

1979-12-19

1981-08-25

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435188, 435814, 435815, C12N 972

Patent

active

042860636

ABSTRACT:
A method for producing a thrombolytic preparation characterized in that among treatment conditions in the urokinase production pH is maintained within the neutral or weakly alkaline range throughout each treatment step to produce a thrombolytic preparation containing urokinase having a molecular weight of 54,000.+-.10,000 as major ingredient.

REFERENCES:
patent: 3950223 (1976-04-01), Yugari et al.
patent: 4066506 (1978-01-01), Johnson et al.
White et al., Biochemistry vol. 5 No. 7, pp. 2160-2169, Jul. 1966.

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