Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Bacteria or actinomycetales
Reexamination Certificate
2006-05-30
2006-05-30
Housel, James (Department: 1648)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Bacteria or actinomycetales
C424S094600, C424S260100, C424S201100, C536S023700, C435S069100
Reexamination Certificate
active
07052689
ABSTRACT:
DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anticancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells.
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Freeman Abbie G.
MacAllister Thomas W
Roberts Joseph
Sethuraman Natarajan
Brown Tim
Housel James
ME Medical Enzymes AG
Roberts Joseph
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