Method for producing tetrazolylbenzene compound

Details Method for producing tetrazolylbenzene compound Method for producing tetrazolylbenzene compound

1995-08-28

1997-02-04

Cook, Rebecca

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D25700

Patent

active

055999433

ABSTRACT:
Disclosed are a compound of the formula (R).sub.3 SnN.sub.3, wherein R is a C.sub.7-18 alkyl, and a process for producing a tetrazolylbenzene compound which comprises reacting a cyanobenzene compound with a (R).sub.3 SnN.sub.3. This process is useful for a safe and commercially profitable production of the tetrazolylbenzene compound which is employed for producing a tetrazole derivative having a hypotensive action based on angiotensin II-antagonizing activity or a production intermediate thereof.

REFERENCES:
patent: 3232958 (1966-02-01), Washington
J. Med. Chem., vol. 34, pp. 2525-2547, (1991).
J. V. Duncia et al., "Three Synthetic Routes to a Sterically Hindered Tetrazole. A New One-Step Mild Conversion of an Amide . . . ", J. Org. Chem., vol. 56, pp. 2396-2400 (1991).

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