Method for producing temperature-sensitive morbillivirus

Details Method for producing temperature-sensitive morbillivirus Method for producing temperature-sensitive morbillivirus

2007-04-24

2007-04-24

Chen, Stacy B. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

C424S212100, C424S213100, C435S069100

Reexamination Certificate

active

10203703

ABSTRACT:
It was found that a mutation of an amino acid at a specific position in the P protein of a morbillivirus gives a temperature-sensitivity character to a virus. By introducing this mutation, a virus to which a temperature-sensitivity character has been introduced can be produced. According to this invention, attenuated viruses useful in the preparation of vaccines can be easily produced.

REFERENCES:
patent: 5654136 (1997-08-01), Sasaki et al.
patent: 5824777 (1998-10-01), Sasaki et al.
patent: 0540135 (1993-05-01), None
Sasaki, Keiko, Studies on the Modification of the Live AIK Measles Vaccine, Kitasato Archives of Experimental Medicine, 47(1-2):1-12, 1974.
Bellini et al., “Measles virus P gene codes for two proteins,”J. Virol.,53(3):908-919 (1985).
Komase et al., “Sendai virus C proteins are categorically nonessential gene products but required for viral assembly,” (1999).
Mori et al., “Molecular cloning and complete nucleotide sequence of genomic RNA of the AIK-C strain of attenuated measles virus,”Virus Genes, 7(1):67-81 (1993).
Vydelingum et al., “Infection of human peripheral blood mononuclear cells with a temperature-sensitive mutant of measles virus,”J. Virol.,63(2):689-695 (1989).

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