Method for producing sterile filterable liposome dispersion

Details Method for producing sterile filterable liposome dispersion Method for producing sterile filterable liposome dispersion

1997-09-30

2000-03-07

Kishore, Gollamudi S.

Food or edible material: processes, compositions, and products

Processes

Preparation of product which is dry in final form

264 41, 264 43, A61K 9127, A61K 9133

Patent

active

060337087

ABSTRACT:
The present invention relates to a composition and method of producing noggregating, filterable dispersion of liposome encapsulated agent or therapeutic of interest, specifically hemoglobin. A key step in the method of the present invention is the addition of a passivating protein prior to hydration of the liposomes with the agent of interest. The resulting dispersion is composed of unilamellar vesicles having a diameter of less than or equal to 0.2 microns.

REFERENCES:
patent: 4229360 (1980-10-01), Schneider
patent: 4746516 (1988-05-01), Moro
patent: 5340587 (1994-08-01), Mihalko
patent: 5589189 (1996-12-01), Monynihan

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